Chromosome determining genetics region sex y



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Evolution of the mammalian Y chromosome and sex-determining genes




The role of the Y-chromosome in sex determination
Some species including humans have a gene SRY on the Y chromosome that determines maleness. This section needs expansion. These initial Sertoli cells, in the center of the gonad, are hypothesized to be the starting point for a wave of FGF9 that spreads throughout the developing XY gonad, leading to further differentiation of Sertoli cells via the up-regulation of SOX9. In Y-centered sex determination, the SRY gene is the main gene in determining male characteristics, but multiple genes are required to develop testes. Sexual differentiation humans Development of the reproductive system gonads Mesonephric duct Paramesonephric duct.






Testis-determining factor




Description: Biology of Reproduction. The cloned region spans the deletion in a female who carries all but kilobases of the Y. However, a smaller gene sequence of 35 kb, the SRY, situated outside the kb ZFY region, has recently been isolated and proved to be the only and the smallest part of the Y chromosome necessary for male sex determination. Genetics Home Reference.
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Date: 03.03.2019
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